Effect of melatonin on blood pressure and aortic relaxation and contraction activity from hypertensive rats / 中国药理学通报

AIM To observe the hypotensive effect of melatonin (MT) on two-kidney one-clip renal hypertensive (2K1C) rats and to explore its aortic mechanism. METHODS 2K1C rats were obtained by narrowing the left kidney artery; systolic blood pressure was measured by use of tail-cuff method; vascular actions of MT were measured using isolated blood vessel method. RESULTS MT reduced blood pressure of 2K1C rat significantly 〔(23.45?2.40) kPa versus (19.81?2.78) kPa, P